If you create a loop from a region in an Audio Instrument track that uses sends to bus effects, and then drag the saved loop to another Audio Instrument track, the new loop will sound different from the original source region. This happens because the effects sends in the original track are not saved with the loop.
Logic Pro and Logic Express do not automatically assign effects to busses because doing so would potentially interfere with bus configurations that you've already set up in your song. However, effects that are inserted directly on the Audio Instrument channel will be automatically recalled when the loop is dragged to the Arrange window from the Loop Browser.
You can do one of the following workarounds to ensure that loops you create from Audio Instrument track regions will sound the same as the original regions: