If you used Mail with Mac OS X 10.3, then upgraded to Mac OS X 10.4 Tiger and imported your Mail mailboxes (messages and attachments), please note that Tiger will not delete some previous mailbox files. Tiger keeps them around just in case you want to back up your Mac OS X 10.3 mailboxes.
This won't pose any issues with your current mailboxes. However, if your previous mailboxes are pretty big—maybe you have lots of attachments or large messages—you might enjoy the disk space you'd get back by deleting them.
If you want Tiger to "devour" those mailboxes to free up some disk, follow these steps:
Important: Do not delete any folders, including ".mbox" folders, ".imapmbox" folders, or "Messages" folders." These are used by Mac OS X 10.4.
Tip: If you don't immediately see available disk space increase, you probably have FileVault home folder protection enabled—simply log out and back in to let FileVault recover disk space.