This might happen if an incompatible third-party device plug-in has been installed, or if a compatible plug-in for the device was removed, or in other situations.
If your phone or device is listed on the iSync Compatibile Devices Page:
If your phone or device is not listed on the iSync Compatibile Devices Page, contact the device's manufacturer to see if a compatible plug-in is available. If no plug-in is available, remove the device/phone from iSync.
Some phones may require the use of a third-party or USB cable to work with iSync. Some Palm devices require that Palm Desktop 4.2.1 or later software be installed; Pocket PC and Palm OS-based PDAs require third-party software.
See also: "iSync 2.2 or later: Some phones may require a firmware update".
Important: Information about products not manufactured by Apple is provided for information purposes only and does not constitute Apple's recommendation or endorsement. Please contact the vendor for additional information.