When using the CD Audio Player application, the playback rate is always 44 kHz, since the sound is coming straight from the CD player.
Capturing Audio
If you are capturing CD audio using a program like Fusion Recorder, the sound out sample option will be a factor. Fusion Recorder will 'take over' the sound settings so that you can not access them through the Sound Control Panel. They must be set within Fusion Recorder. The application is modifying the same settings that the Sound Control Panel adjust and more. Fusion Recorder tells the Macintosh's Sound Manager to route sound from the selected input source through the sound chip during recording or monitoring.
When recording with Fusion Recorder, adjust the sound settings to match the sample rate you want to capture. When choosing a sample rate, remember that the size of the file is based on the quality of the recording. Capturing audio at 44 kHz, produces a much larger file than one captured using 22 kHz.
Fusion Recorder does not have a playthrough option, so any sound you hear using the application is played at the sample rate the recording is done at which could be either 22 kHz or 44 kHz. The application is designed this way so you can 'monitor' the quality of the sound being recorded based on your sound settings. A playthrough option would not give an accurate representation of the sound being recorded.
Sound digitizing applications override the Sound control panel settings. So if you are listening to a CD using a sound application like Fusion Recorder, you may not hear the full quality of the sound.