We believe you encountered a ColorSync 2.0.1 problem that should be addressed in a future release of ColorSync. What is likely happening is a ColorSync PPC library code fragment is not getting unloaded. Although the memory fragment is small in size, if it is the middle of a large contiguous block of memory, then the "Largest Unused Block" of memory is reduced proportionately.
As you have discovered, the workaround is to quit the application then restart your Macintosh computer. To minimize the problem, minimize the launching. You should also quit the Dispatcher software before launching and working with your other applications that require a lot of RAM.