In order for the software to see all of the four ports on the card, you must have the CSI server extension loaded at startup. When this software loads it initializes the card. Even though this is non-Apple software, it is necessary.
Open the Remote Access Manager Application that is installed on the hard drive in the Remote Access MP folder. Under the Server Menu, there is an option for Configure Ports. This opens the port information window.
Look in the port information window to see how many ports are available (with one card, it will say, "4 out of 4."
If the card is not initialized or loaded properly, it will say "0 out of 4." The extension to initialize the card is included on the CSI disk.
The Remote Access MultiPort software will not allow you to "serve out" the built-in serial ports on a Nubus-based Macintosh computer.