Yes, this is a known issue. Apple has reported these Mayo Clinic Family Health CD v2.0 issues to IVI Publishing this titles developer. This title currently ships with the Macintosh Performa 6360 and 6400 computers.
To avoid the "Please insert the Health Disk 2.0 CD in drive F: before running the program." message, make sure you have the compact disc in the CD-ROM drive before launching the Family Health application.
For the latest information regarding these issues, contact IVI Publishing at:
IVI Publishing
Phone: (612) 996-6300
Internet:
http://www.ivi.com